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His career continued beyond Buffy. Brendon later appeared in television projects including Kitchen Confidential and Criminal Minds, where he played technical analyst Kevin Lynch. He also worked in other television and film productions, giving audiences the opportunity to see different sides of his acting abilities. For viewers discovering his work years later, these roles offered another reminder of the range he brought to the screen.
In the years before his death, Brendon faced several significant personal and health challenges. His family had spoken about his passion for painting and art, describing him as someone who remained creative and driven. Later reporting also revealed that he had experienced serious cardiovascular and other health problems. The coroner ultimately determined that cardiovascular disease was the primary cause of death, while acute pneumonia and a previous heart attack were contributing factors.
Away from the headlines, Brendon leaves behind a body of work that continues to be revisited by television audiences. His portrayal of Xander gave viewers a character who was imperfect but dependable, humorous but vulnerable, and often brave when circumstances demanded it. That combination helped make the role memorable and allowed audiences to connect with him in a personal way.